Biochem/physiol Actions

Integrin subunit α 4 (ITGA4) has a role in bone marrow homing. It associates with the β1 integrin chain and forms the very-late-antigen-4 (VLA-4) complex. The protein also binds to vascular cell adhesion molecule-1, fibronectin and osteopontin (OPN) and modulates the activity of immature progenitors in the bone marrow. ITGA4 also aids the migration of B lymphocytes through the fibroblast barrier.

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General description

Integrin subunit α4 (ITGA4) is an adhesive factor, that is part of the integrin family. The gene encoding it is localized on human chromosome 2q31.3.

Immunogen

Synthetic peptide corresponding to the C-terminus of human Integrin alpha 4 (ITGA4)

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Specificity

This antibody reacts to the cytoplasmic domain of human Integrin alpha 4 (ITGA4).